Ligandrol (LGD-4033)
4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile. Selective Androgen Receptor Modulator (SARM), non-steroidal sarm.
This page describes what Ligandrol (LGD-4033) is and its known risks. It is not medical advice and not a guide to using it. Many of these substances are prescription-only or illegal to use without a prescription. Speak to a doctor.
- Class
- Selective Androgen Receptor Modulator (SARM)
- Legal status
- Research chemical (not approved for human use)
- Half-life
- 24-36 hours
- Liver strain
- Low
- Kidney strain
- Low
- Converts to estrogen
- None
- Suppresses natural hormones
- Yes
Medical uses
- None (clinical trials for muscle wasting)
What it does in the body
Anabolic
- Significant lean muscle gain
- Strength increase
- Fat loss (mild)
- Bone density increase
- Enhanced recovery
Forms, half-life and detection
| Form | Half-life | Reported detection window |
|---|---|---|
| Oral (liquid or capsules) | 24-36 hours | Unknown (detected in drug tests) |
Side effects and health risks
Hormones and fertility
- Testosterone suppression (moderate to significant)
- Reduced HDL cholesterol
- Increased LDL cholesterol
Liver
- Elevated liver enzymes (rare)
Other
- Headaches
- Nausea
- Fatigue
Blood tests worth monitoring
From its known properties, these are the markers doctors commonly check. Getting blood work before, during and after is how problems are caught early.
- Androgens tend to lower HDL, raise LDL and thicken the blood: HDL Cholesterol, LDL Cholesterol, Hematocrit, Hemoglobin
- Shuts down natural production (PCT needed): Total Testosterone, LH, FSH
Related compounds
Questions
What is the half-life of Ligandrol (LGD-4033)?
About 24-36 hours. Half-life is the time for the level in the blood to fall by half.
How long is Ligandrol (LGD-4033) detectable?
Testing windows of Unknown (detected in drug tests) are reported, depending on the test and the person.
Is Ligandrol (LGD-4033) legal?
Research chemical (not approved for human use). Laws differ by country and change; check the rules where you live.
What blood tests matter with Ligandrol (LGD-4033)?
Based on its properties, these markers are commonly monitored: HDL Cholesterol, LDL Cholesterol, Hematocrit, Hemoglobin, Total Testosterone, LH and FSH. A doctor can order and interpret them.
What are the side effects of Ligandrol (LGD-4033)?
Hormones and fertility: testosterone suppression (moderate to significant), reduced hdl cholesterol and increased ldl cholesterol. Liver: elevated liver enzymes (rare). Other: headaches, nausea and fatigue.
For information only, not medical advice. MyoStats is a tracking tool used at your own discretion. Speak to a doctor before changing your training, diet, medication or anything you take.