Andarine (S4)
S-4 (4-[(4R)-3-(4-hydroxybutyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-methyl-3-(trifluoromethyl)benzonitrile analogue). Selective Androgen Receptor Modulator (SARM), non-steroidal sarm.
This page describes what Andarine (S4) is and its known risks. It is not medical advice and not a guide to using it. Many of these substances are prescription-only or illegal to use without a prescription. Speak to a doctor.
- Class
- Selective Androgen Receptor Modulator (SARM)
- Legal status
- Research chemical (not approved for human use)
- Half-life
- 4-6 hours (short, requires split dosing)
- Liver strain
- Low-Moderate
- Kidney strain
- Low
- Converts to estrogen
- None
- Suppresses natural hormones
- Yes
Medical uses
- None (research for muscle wasting and osteoporosis)
What it does in the body
Anabolic
- Muscle hardness and density
- Fat loss
- Mild strength increase
- No water retention
Forms, half-life and detection
| Form | Half-life | Reported detection window |
|---|---|---|
| Oral (liquid or capsules) | 4-6 hours (short, requires split dosing) | Unknown |
Side effects and health risks
Hormones and fertility
- Testosterone suppression (mild-moderate)
Visual
- Yellow-tinted vision (night vision issues, reversible)
- Reduced ability to adapt to darkness
Liver
- Elevated liver enzymes (mild)
Other
- Headaches
Blood tests worth monitoring
From its known properties, these are the markers doctors commonly check. Getting blood work before, during and after is how problems are caught early.
- Androgens tend to lower HDL, raise LDL and thicken the blood: HDL Cholesterol, LDL Cholesterol, Hematocrit, Hemoglobin
- Shuts down natural production (PCT needed): Total Testosterone, LH, FSH
Related compounds
Questions
What is the half-life of Andarine (S4)?
About 4-6 hours (short, requires split dosing). Half-life is the time for the level in the blood to fall by half.
How long is Andarine (S4) detectable?
Testing windows of Unknown are reported, depending on the test and the person.
Is Andarine (S4) legal?
Research chemical (not approved for human use). Laws differ by country and change; check the rules where you live.
What blood tests matter with Andarine (S4)?
Based on its properties, these markers are commonly monitored: HDL Cholesterol, LDL Cholesterol, Hematocrit, Hemoglobin, Total Testosterone, LH and FSH. A doctor can order and interpret them.
What are the side effects of Andarine (S4)?
Hormones and fertility: testosterone suppression (mild-moderate). Visual: yellow-tinted vision (night vision issues, reversible) and reduced ability to adapt to darkness. Liver: elevated liver enzymes (mild).
For information only, not medical advice. MyoStats is a tracking tool used at your own discretion. Speak to a doctor before changing your training, diet, medication or anything you take.