Yohimbine
17α-hydroxy-yohimban-16α-carboxylic acid methyl ester. Alpha-2 Adrenergic Antagonist, stimulant / fat-loss aid.
This page describes what Yohimbine is and its known risks. It is not medical advice and not a guide to using it. Many of these substances are prescription-only or illegal to use without a prescription. Speak to a doctor.
- Class
- Alpha-2 Adrenergic Antagonist
- Legal status
- Over-the-counter supplement (USA, varies elsewhere)
- Half-life
- 0.5-2 hours (short)
- Liver strain
- Low
- Kidney strain
- Low
- Converts to estrogen
- None
- Suppresses natural hormones
- Not typically
Medical uses
- Erectile dysfunction (historical, largely superseded)
- Orthostatic hypotension (rare use)
What it does in the body
Metabolic
- Increased fat mobilization (particularly stubborn areas via alpha-2 receptor blockade)
- Increased energy/alertness
Forms, half-life and detection
| Form | Half-life | Reported detection window |
|---|---|---|
| Oral | 0.5-2 hours (short) | 1-2 days |
Side effects and health risks
Heart and blood vessels
- Increased heart rate
- Increased blood pressure
- Palpitations
Neurological
- Anxiety
- Jitteriness
- Insomnia if taken late
Gastrointestinal
- Nausea (common, especially fasted)
Questions
What is the half-life of Yohimbine?
About 0.5-2 hours (short). Half-life is the time for the level in the blood to fall by half.
How long is Yohimbine detectable?
Testing windows of 1-2 days are reported, depending on the test and the person.
Is Yohimbine legal?
Over-the-counter supplement (USA, varies elsewhere). Laws differ by country and change; check the rules where you live.
What blood tests matter with Yohimbine?
Ask a doctor which tests suit you.
What are the side effects of Yohimbine?
Heart and blood vessels: increased heart rate, increased blood pressure and palpitations. Neurological: anxiety, jitteriness and insomnia if taken late. Gastrointestinal: nausea (common, especially fasted).
For information only, not medical advice. MyoStats is a tracking tool used at your own discretion. Speak to a doctor before changing your training, diet, medication or anything you take.