Estradiol (E2) blood test
The main estrogen. In men it is made mostly from testosterone by the aromatase enzyme, and it matters for bones, libido and mood.
- Typical range (adult men)
- 10–40 pg/mL
- Panel
- Hormones
- Also called
- E2, Oestradiol
Reference ranges vary between labs; use the range on your own report. Results need to be read by a doctor alongside your symptoms and other tests.
Why it’s tested
Higher testosterone usually means higher estradiol. Both too high and too low cause symptoms, which is why it is tested with testosterone.
What can raise it
- High testosterone levels, including from use of testosterone
- Higher body fat (more aromatase)
- Liver disease
- Some medications
What can lower it
- Low testosterone
- Aromatase inhibitor use
Getting an accurate result
- Test in the morning, especially for hormones, which run highest early in the day.
- Stay hydrated, and test at the same lab and time of day each time so results compare fairly.
Compounds that affect Estradiol (E2)
Monitored with these, based on their known properties:
- Testosterone Cypionate
- Testosterone Enanthate
- Testosterone Propionate
- Dianabol (Methandrostenolone)
- HCG (Human Chorionic Gonadotropin)
- HMG (Human Menopausal Gonadotropin)
- Sustanon 250
- Testosterone Undecanoate (Nebido/Aveed)
- Testosterone Suspension
- DHEA (Dehydroepiandrosterone)
Other hormones tests
Questions
What is a normal Estradiol (E2) level?
A typical adult male reference range is 10–40 pg/mL. Ranges differ for women, by age and between labs, so compare with the range printed on your report.
What does high Estradiol (E2) mean?
Common reasons include high testosterone levels, including from use of testosterone, higher body fat (more aromatase), liver disease and some medications. One result outside the range isn't a diagnosis: a doctor will look at it with your other markers and history.
What does low Estradiol (E2) mean?
Common reasons include low testosterone and aromatase inhibitor use.